Dichloromethane → HCID 67067838, compound

HRID 1037405Notes

Reaction equation

[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[C:22](Br)[CH:23]=[CH:24][CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].ClCCl.C(N(CC)CC)C>CO>[CH3:1][O:5][C:6]([C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:21]=1[O:20][C:19]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[C:18]([C:15]1[CH:16]=[CH:17][C:12]([C:8]3([NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:36])[CH2:11][CH2:10][CH2:9]3)=[CH:13][CH:14]=1)[C:27]2=[O:28])=[O:36]

Participants

Conditions

Temperature: 50 °C

Procedure

{1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (200 mg, 0.367 mmol), and [1,1′-bis(diphenylphosphino)-ferrocene]dischloropalladium(II) complex with dichloromethane (60 mg, 0.073 mmol) were loaded into a microwave vial. The vial was sealed and a solution of triethylamine (0.102 mL, 0.732 mmol) in MeOH (4 mL) was added. The vial was evacuated and flushed twice with argon, followed by carbon monoxide. The reaction mixture was heated conventionally at 50° C. under an atmosphere of carbon monoxide for 18 h. The reaction mixture was allowed to cool to RT and was concentrated in vacuo. The resultant residue was subjected to flash chromatography (SiO2, gradient 0 to 10% EtOAc in DCM) to give the title compound as a gum (193 mg, 100%). LCMS (Method G): RT=4.41 min, [M+H]+=526.

Workup

customThe vial was sealed
customThe vial was evacuated
customflushed twice with argon
temperatureto cool to RT
concentrationwas concentrated in vacuo

Sources & evidence

ORD record: ord-8dcb59a87b64480fbc8f541dc426c8b6
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546376B2

Reaction notes

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