反应详情

Compound (46) was prepared in a similar manner to the synthesis of Compound (44) with the following variation: 4-bromo-3-fluoroaniline was used instead of 4-chloroaniline at Step d. ESI-MS m/z [M+H]+: 481.1. 1H NMR (400 MHz, DMSO) δ 9.21 (brs, 1H), 8.67 (brs, 1H), 7.96-7.83 (m, 2H), 7.76-7.62 (m, 2H), 7.45-7.30 (m, 2H), 3.10 (s, 3H), 2.90-2.76 (m, 3H), 2.31-2.20 (m, 1H), 1.07-0.92 (m, 2H), 0.80-0.66 (m, 2H).