HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1037562Generated: October 31, 2026
Sodium Bicarbonate → 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxylic acid
https://huagongshe.com/reaction/1037562
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxamide | HCID 67776345 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxylic acid | HCID 67512739 | 35% |
Reaction Steps
A stirred suspension of compound (xv) in conc. sulfuric acid (5 mL) and water (5 mL) were heated to 90° C. After 2 h the reaction mixture was diluted with water, neutralized with sodium bicarbonate and extracted with EtOAc (3×15 mL). The organic layer was dried (Na2SO4) and concentrated to give 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxylic acid (xvi) (70 mg, 35%) as a white solid. ESI-MS m/z calculated for [M+H]+: 336.98; found: 336.80.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08546389B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-640b76f069e5438c8a4e1fca0ee75a37 |
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| Source note | uspto-grants-2013_10 |
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