Propanoic acid, 2-bromo-2-methyl-, ethyl ester → Ethyl 2-(acetylthio)-2-methylpropanoate

HRID 1037572Notes

Reaction equation

HRID 1037572 reaction equation
Br[C:2]([CH3:9])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:10]([O-:13])(=[S:12])[CH3:11].[K+]>CN(C)C=O>[CH2:6]([O:5][C:3](=[O:4])[C:2]([S:12][C:10](=[O:13])[CH3:11])([CH3:9])[CH3:8])[CH3:7]

Participants

4

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 23670855Potassium ethanethioate

Product 1

HCID 57937863Ethyl 2-(acetylthio)-2-methylpropanoate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of ethyl α-bromoisobutyrate (62 g, 0.32 mol) in N,N-dimethylformamide (500 mL) at room temperature is added potassium thioacetate (72 g, 0.63 mol). The reaction is stirred for 16 h and then concentrated under reduced pressure. The residue is diluted with a 2M aqueous hydrochloric acid solution (500 mL) and extracted with ethyl acetate (3×500 mL). The organic fractions are combined, washed with brine (300 mL), dried (MgSO4), filtered and concentrated under reduced pressure. Purification by chromatography on silica eluting with heptanes/dichloromethane provides the title compound, m/z 191 [M+H+].

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue is diluted with a 2M aqueous hydrochloric acid solution (500 mL)
  3. extractionextracted with ethyl acetate (3×500 mL)
  4. washwashed with brine (300 mL)
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customPurification by chromatography on silica eluting with heptanes/dichloromethane

Sources & evidence

ORD record
ord-ed0571ac10c249759d312a19ed7f0aa0
Source dataset
uspto-grants-2013_10
Patent number
US08546563B2

Reaction notes

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