反应详情

To a solution of 2-(azetidine-1-sulfinyl)-2-methyl-propionic acid ethyl ester (4.62 g, 21 mmol) in dichloromethane (100 mL) at room temperature is added meta-chloroperbenzoic acid (5.46 g, 32 mmol). The reaction is stirred for 1 h before Ambersep 900-OH resin (2.9 g) is introduced. The suspension is shaken for 2 h and then filtered. The filtrate is concentrated under reduced pressure and the residue is re-dissolved in dichloromethane (50 mL), washed with a saturated solution of sodium bicarbonate (50 mL) and the solvent is concentrated under reduced pressure to provide the title compound as an orange oil. This oil is used without further purification, m/z 236 [M+H+].

1. additionis introduced
2. filtrationfiltered
3. concentrationThe filtrate is concentrated under reduced pressure
4. dissolutionthe residue is re-dissolved in dichloromethane (50 mL)
5. washwashed with a saturated solution of sodium bicarbonate (50 mL)
6. concentrationthe solvent is concentrated under reduced pressure