HCID 15588634, compound → HCID 13615297, compound

HRID 1037609Notes

Reaction equation

HRID 1037609 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=2[NH:22]C(=O)C(C)(C)C)(O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCCCO.Cl>[CH2:1]([N:8]1[CH2:9][CH:10]=[C:11]([C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=2[NH2:22])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 15588634HCID 15588634, compound

Product 1

HCID 13615297HCID 13615297, compoundYield 47.2%

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 313Hydrochloric AcidSolvent

Procedure

A suspension of N-[2-(1-benzyl-4-hydroxy-piperidin-4-yl)-4-chloro-phenyl]-2,2-dimethyl-propionamide (6.00 g) in n-BuOH (50 ml) and 6N HCl (120 ml) was heated to reflux temperature for 5 days. The solution was then poured into ice water, made acidic with cone. HCl and extracted with ethyl acetate. The water layer was made basic and extracted three times with CH2Cl2, dried over sodium sulfate and concentrated in vacuo. The residue was subjected to silica gel chromatography (hexane:ethyl acetate:triethyl amine 49:49:2) to afford 2-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-4-chloro-phenylamine (2.11 g; viscous oil; Retention Time HPLC 1.81 min; MS (ES+) 299 (M+H)) and 4-(2-amino-5-chloro-phenyl)-1-benzyl-piperidin-4-ol (2.11 g; viscous oil; Retention Time HPLC 1.58 min; MS (ES+) 317 (M+H−).

Workup

  1. temperaturewas heated
  2. temperatureto reflux temperature for 5 days
  3. extractionHCl and extracted with ethyl acetate
  4. extractionextracted three times with CH2Cl2
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-34a2b55e712443f993634fae456a8717
Source dataset
uspto-grants-2013_10
Patent number
US08546569B2

Reaction notes

Loading…