HCID 86627645, compound → HCID 86627646, compound

HRID 1037611Notes

Reaction equation

HRID 1037611 reaction equation
[Cl:1]C(OC([N:7]1[CH2:12][CH:11]=[C:10]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[NH:20][C:21]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([Cl:29])[CH:24]=2)=[O:22])[CH2:9][CH2:8]1)=O)C>CO>[ClH:1].[Cl:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][N:26]=1)[C:21]([NH:20][C:14]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=1[C:10]1[CH2:11][CH2:12][NH:7][CH2:8][CH:9]=1)=[O:22]

Participants

3

Reactant 1

HCID 86627645HCID 86627645, compound

Product 1

HCID 86627646HCID 86627646, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Crude 4-{5-chloro-2-[(2-chloro-pyridine-4-carbonyl)-amino]phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid 1-chloro-ethyl ester (550 mg) was dissolved in methanol (25 ml) in and heated to reflux for 16 hours. Evaporation afforded the crude title product (465 mg). Retention Time HPLC 1.48 min; MS (ES+) 350, 348 (M+H+).

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. customEvaporation

Sources & evidence

ORD record
ord-85987eeeb8e242d6baf874b64db82002
Source dataset
uspto-grants-2013_10
Patent number
US08546569B2

Reaction notes

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