HRID1037630

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5

HCID9848990

未命名化合物

PRODUCTS

生成物

结构：CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5.Cl

HCID9848989

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Conc. HCl (2.6 L) was added to the filtered solution of buprenorphine base (9.65 Kg) in acetone (68 L) at below 15° C. to get pH below 2.0 and stirred for 1.0-2.0 hrs. The HCl salt firmed was filtered, washed with acetone and finally leached with filtered DM water (28 L) at 80° C. and dried. Yield=8.42 Kg.

WORKUP

后处理

customto get pH below 2.0
filtrationThe HCl salt firmed was filtered
washwashed with acetone
customfinally leached with filtered DM water (28 L) at 80° C.
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-24f32c6732c940fa87e77ddab1cb1687
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546572B2
来源说明: uspto-grants-2013_10

反应 SMILES

[ClH:1].[CH3:2][C@@:3]([OH:35])([C:31]([CH3:34])([CH3:33])[CH3:32])[C@@H:4]1[C@:9]2([O:29][CH3:30])[C@@H:10]3[O:24][C:19]4=[C:20]([OH:23])[CH:21]=[CH:22][C:17]5=[C:18]4[C@:11]43[CH2:12][CH2:13][N:14]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[C@H:15]([CH2:16]5)[C@@:6]4([CH2:7][CH2:8]2)[CH2:5]1>CC(C)=O>[CH3:2][C@@:3]([OH:35])([C:31]([CH3:34])([CH3:33])[CH3:32])[C@@H:4]1[C@:9]2([O:29][CH3:30])[C@@H:10]3[O:24][C:19]4=[C:20]([OH:23])[CH:21]=[CH:22][C:17]5=[C:18]4[C@:11]43[CH2:12][CH2:13][N:14]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[C@H:15]([CH2:16]5)[C@@:6]4([CH2:7][CH2:8]2)[CH2:5]1.[ClH:1]