反应详情

温度

120 °C

11.66 g of ethyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, 10.29 g of potassium carbonate, 0.67 ml of water and 912.4 mg of [1,1′-bis-(diphenylphosphino)ferrocene]palladium(II)dichloride are added to a solution of 15 g of 2-amino-6-iodo-4-(1,3-dihydroisoindol-2-ylcarbonyl)quinazoline in 200 ml of ethanol under argon. The mixture is heated at 120° C. for min, giving a clear solution. The hot solution is filtered through kieselguhr. On cooling, ethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate crystallises out.

1. customgiving a clear solution
2. filtrationThe hot solution is filtered through kieselguhr
3. temperatureOn cooling
4. customethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate crystallises out