Diethylamine → 2-bromo-N,N-diethyl-4,5-difluorobenzamide

HRID 1037683Notes

Reaction equation

HRID 1037683 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[O:5]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 27832942-Bromo-4,5-difluorobenzoyl chloride

Product 1

HCID 584572002-bromo-N,N-diethyl-4,5-difluorobenzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1.05 g of 2-bromo-4,5-difluorobenzoyl chloride in 5 ml of DCM are added dropwise with stirring to a solution of 846.9 μl of diethylamine in 5 ml of DCM. The mixture is subsequently stirred at RT for 1 h. The mixture is then extracted a number of times against water (pH 9), the organic phase is dried and purified by column chromatography.

Workup

  1. extractionThe mixture is then extracted a number of times against water (pH 9)
  2. customthe organic phase is dried
  3. custompurified by column chromatography

Sources & evidence

ORD record
ord-073503cc5e7d49dd9f6bbd5e57765372
Source dataset
uspto-grants-2013_10
Patent number
US08546565B2

Reaction notes

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