反应详情

温度

22 °C

A solution of 58 μl of dimethylpyrrolidine in 4 ml of THF is added dropwise to a solution of 400 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzenesulfonyl chloride in 4 ml of THF with ice-cooling. The mixture is subsequently stirred at 22° C. for a further 1 h, evaporated in vacuo and taken up in 4 ml of diethyl ether. The solution is washed 3 times against sodium hydroxide solution (2N) and finally purified by column chromatography.

1. temperaturecooling
2. customevaporated in vacuo
3. washThe solution is washed 3 times against sodium hydroxide solution (2N)
4. customfinally purified by column chromatography