反应详情

Into a round bottom flask was combined 5-nitro-isochromen-1-one (1.5 g, 0.0071 mol), 2-(methylsulfonyl)ethanamine hydrochloride (2.2 g, 0.014 mol) and methanol (45 mL, 1.1 mol). The mixture was heated at reflux for 1.5 hours. The mixture was cooled to room temperature and was concentrated to yield a yellow solid. The solid was taken onto the next step without further purification.

1. customInto a round bottom flask was combined
2. temperatureThe mixture was heated
3. temperatureat reflux for 1.5 hours
4. concentrationwas concentrated
5. customto yield a yellow solid
6. customThe solid was taken onto the next step without further purification