Methanol → 2-(2-(Methylsulfonyl)ethyl)-5-nitroisoquinolin-1(2H)-one

Participants

Reaction Steps

Into a round bottom flask was combined 5-nitro-isochromen-1-one (1.5 g, 0.0071 mol), 2-(methylsulfonyl)ethanamine hydrochloride (2.2 g, 0.014 mol) and methanol (45 mL, 1.1 mol). The mixture was heated at reflux for 1.5 hours. The mixture was cooled to room temperature and was concentrated to yield a yellow solid. The solid was taken onto the next step without further purification.

Provenance & Evidence