反应详情

A mixture of the product of Example 25A (0.27 g, 1.3 mmol) in 40% aqueous potassium hydroxide was stirred for 6 hours. The mixture was then diluted with water, made slightly acidic by the addition of 2 N aqueous HCl, and then extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 0.25 g of the title compound.

1. extractionextracted three times with ethyl acetate
2. dry with materialThe combined organic extracts were dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure