2-Aminothiazole → 3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylideneamine hydrobromide
Reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[Br:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1>>[BrH:7].[O:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]1[CH2:8][N:6]1[CH:5]=[CH:4][S:3][C:2]1=[NH:1]Participants
3
Procedure
A mixture of 2-aminothiazole and 2-(bromomethyl)tetrahydro-2H-pyran were processed using the method described in Example 12A to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.
Sources & evidence
- ORD record
- ord-64dc94712abd43838d6a73bc82cd99a3
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08546583B2
Reaction notes
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