Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 58418305 | HCID 58418305 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58418235 | HCID 58418235 | — |
Reaction Steps
To a solution of methyl 5-(1-(3-cyclopentylureido)ethyl)thiophene-2-carboxylate obtained from step 1 in tetrahydrofuran (1 mL) and methanol (0.5 mL) was added 1.0 M aqueous NaOH (0.5 mL) and the reaction solution was heated to 40° C. for 8 hours. The reaction was neutralized with the addition of 1M aqueous HCl (0.5 mL) and the solution was evaporated to dryness to afford 5-(1-(3-cyclopentylureido)ethyl)thiophene-2-carboxylic acid. LC-MS: (FA) ES+ 283.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08546588B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-b4192c509d314a04b9e2ba44d70dd26d |
|---|
| Source note | uspto-grants-2013_10 |
|---|
