Hydrochloric Acid → HCID 58418235, compound

HRID 1037957Notes

Reaction equation

HRID 1037957 reaction equation
[CH:1]1([NH:6][C:7](=[O:20])[NH:8][CH:9]([C:11]2[S:15][C:14]([C:16]([O:18]C)=[O:17])=[CH:13][CH:12]=2)[CH3:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>O1CCCC1.CO>[CH:1]1([NH:6][C:7](=[O:20])[NH:8][CH:9]([C:11]2[S:15][C:14]([C:16]([OH:18])=[O:17])=[CH:13][CH:12]=2)[CH3:10])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58418305HCID 58418305, compound

Product 1

HCID 58418235HCID 58418235, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of methyl 5-(1-(3-cyclopentylureido)ethyl)thiophene-2-carboxylate obtained from step 1 in tetrahydrofuran (1 mL) and methanol (0.5 mL) was added 1.0 M aqueous NaOH (0.5 mL) and the reaction solution was heated to 40° C. for 8 hours. The reaction was neutralized with the addition of 1M aqueous HCl (0.5 mL) and the solution was evaporated to dryness to afford 5-(1-(3-cyclopentylureido)ethyl)thiophene-2-carboxylic acid. LC-MS: (FA) ES+ 283.

Workup

  1. customthe solution was evaporated to dryness

Sources & evidence

ORD record
ord-b4192c509d314a04b9e2ba44d70dd26d
Source dataset
uspto-grants-2013_10
Patent number
US08546588B2

Reaction notes

Loading…