反应详情

A solution of 2-(1,3-dioxolan-2-yl)thiazole-5-carboxylic acid (20 g, 0.1 mol) in hydrochloric acid (1000 mL, 3 N) and acetone (1000 mL) was heated to reflux for 6 h. The solution was then extracted with ether (5×500 mL). The combined organic phases were dried (Na2SO4) and concentrated. Flash column chromatography (petroleum ether:EtOAc, 100:1 to 5:1) afforded 2-formylthiazole-5-carboxylic acid (36 g, 76%). %). 1H NMR (DMSO-d6, 300 MHz) δ 13.90 (br, 1H), 9.92 (s, 1H), 8.63 (s, 1H).

1. temperatureto reflux for 6 h
2. extractionThe solution was then extracted with ether (5×500 mL)
3. dry with materialThe combined organic phases were dried (Na2SO4)
4. concentrationconcentrated