1,4-Dioxane hydrochloride → 2-(4-(Piperazin-1-yl)phenyl)pyrimidine

HRID 1037983Notes

Reaction equation

HRID 1037983 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:25]=[CH:24][CH:23]=[CH:22][N:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1.Cl>ClCCl>[N:11]1([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:21]=[CH:22][CH:23]=[CH:24][N:25]=3)=[CH:16][CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59511347tert-Butyl 4-(4-(pyrimidin-2-yl)phenyl)piperazine-1-carboxylate

Product 1

HCID 534203192-(4-(Piperazin-1-yl)phenyl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(4-Pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 5.03 gm was dissolved in 25 ml dichloromethane and 10 ml of 4N HCl dioxane added. After stirring for 2 hrs, the mixture was then evaporated to obtain the title product.

Workup

  1. customthe mixture was then evaporated

Sources & evidence

ORD record
ord-576ca56be2c14661b3e0824820097fd5
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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