HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 2-(4-(Piperazin-1-yl)phenyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | tert-Butyl 4-(4-(pyrimidin-2-yl)phenyl)piperazine-1-carboxylate | HCID 59511347 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-(Piperazin-1-yl)phenyl)pyrimidine | HCID 53420319 | — |
Reaction Steps
4-(4-Pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 5.03 gm was dissolved in 25 ml dichloromethane and 10 ml of 4N HCl dioxane added. After stirring for 2 hrs, the mixture was then evaporated to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-576ca56be2c14661b3e0824820097fd5 |
| Source note | uspto-grants-2013_10 |