反应详情

Amine 24 (82 mg, 0.41 mmol) and carboxylic acid 12 (81 mg, 0.21 mmol) were dissolved in CH2Cl2 (2 mL) and DMF (2 ML). To the crude was added TEA (1.16 mL), and HATU (156 mg, 0.41 mmol). The crude was stirred at rt for 22 hrs under a stream of nitrogen. The crude was quenched with sat. NaHCO3 at rt and filtered over a plug of silica gel. The crude was evaporated and purified via preparation plates to give 17 mg of the product.

1. customThe crude was quenched with sat. NaHCO3 at rt
2. filtrationfiltered over a plug of silica gel
3. customThe crude was evaporated
4. custompurified via preparation plates