反应详情

3-Bromo-5-nitro-1H-indazole (0.5 gm, 2 mmol) was dissolved in 3.5 ml of morpholine and heated in a sealed tube for 40 hrs. The mixture was then cooled and added to ethylacetate, washed with brine and dried over magnesium sulfate. After chromatography on silica gel using 20-50% ethylacetate/hexanes as eluent the title compound was obtained (210 mg, 0.85 mmol).

1. temperatureheated in a sealed tube for 40 hrs
2. temperatureThe mixture was then cooled
3. washwashed with brine
4. dry with materialdried over magnesium sulfate