1H-Indazole, 3-(4-morpholinyl)-5-nitro- → 3-Morpholino-1H-indazol-5-amine

HRID 1037994Notes

Reaction equation

HRID 1037994 reaction equation
[N:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([N+:16]([O-])=O)[CH:14]=3)[NH:9][N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.[H][H]>[N:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([NH2:16])[CH:14]=3)[NH:9][N:8]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 30513261H-Indazole, 3-(4-morpholinyl)-5-nitro-

Product 1

HCID 30798583-Morpholino-1H-indazol-5-amine

Reagents, catalysts & solvents 2

HCID 178418361HCID 178418361, compoundCatalystHCID 887MethanolSolvent

Procedure

3-Morpholin-4-yl-5-nitro-1H-indazole (210 mg) was dissolved in 10 ml of methanol and the mixture hydrogenated at 1 atm of hydrogen using 10% Pd/C (50 mg) as catalyst. After 24 hrs, the mixture was filtered and evaporated for use in the next step.

Workup

  1. filtrationthe mixture was filtered
  2. customevaporated for use in the next step

Sources & evidence

ORD record
ord-cae09478cbda4e4582b5f19178b28be9
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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