反应详情

Ammonium formate (50 mg, 0.792 mmol) and 10% Pd/C (5 mg) were added to a solution of 3-(2-fluoro-benzyl)-5-nitro-1H-indazole (50 mg, 0.184 mmol) in MeOH/THF (3 ml, 1/1) then refluxed for 3 hours. The reaction was diluted with MeOH (20 ml) and filtered through a celite pad. The solvent was evaporated, residue dissolved in MeCl2, dried over Na2SO4, filtered and solvent evaporated yielding title compound as white solid (40 mg, 88%) ESMS (MH, 242).

1. temperaturethen refluxed for 3 hours
2. filtrationfiltered through a celite pad
3. customThe solvent was evaporated
4. dissolutionresidue dissolved in MeCl2
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customsolvent evaporated