Trifluoroacetic acid → 1-Carboxymethyl-3-methoxymethyl-pyrrolidine-3-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3]([C:5]1([CH2:18][O:19][CH3:20])[CH2:9][CH2:8][N:7]([CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])[CH2:6]1)=[O:4].FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]([C:5]1([CH2:18][O:19][CH3:20])[CH2:9][CH2:8][N:7]([CH2:10][C:11]([OH:13])=[O:12])[CH2:6]1)=[O:4]Participants
3
Procedure
The 1-tert-butoxycarbonylmethyl-3-methoxymethyl-pyrrolidine-3-carboxylic acid methyl ester (118 mg) was treated with trifluoroacetic acid (2 ml), stirred for 20 minutes and evaporated to a residue that was exchanged with hydrochloric acid (1 ml, 4N) and lyophilized overnight to a gummy title product.
Workup
- customevaporated to a residue that
- waitlyophilized overnight to a gummy title product
Sources & evidence
- ORD record
- ord-a5c9cf99843d4f04b821e3ee6fe699d3
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08546404B2
Reaction notes
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