Toluene methanol → 3-(2-Cyclopropyl-pyridin-4-yl)-1-trityl-1H-indazol-5-ylamine

HRID 1038055Notes

Reaction equation

HRID 1038055 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([C:10]3[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([N+:19]([O-])=O)[CH:17]=4)[N:12]([C:22]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:11]=3)[CH:7]=[CH:6][N:5]=2)[CH2:3][CH2:2]1.CO.C1(C)C=CC=CC=1>[Pd]>[CH:1]1([C:4]2[CH:9]=[C:8]([C:10]3[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([NH2:19])[CH:17]=4)[N:12]([C:22]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)([C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[N:11]=3)[CH:7]=[CH:6][N:5]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 21867641Toluene methanolHCID 576862763-(2-Cyclopropyl-pyridin-4-yl)-5-nitro-1-trityl-1H-indazole

Product 1

HCID 576858383-(2-Cyclopropyl-pyridin-4-yl)-1-trityl-1H-indazol-5-ylamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-(2-Cyclopropyl-pyridin-4-yl)-5-nitro-1-trityl-1H-indazole (2 gm) was dissolved in 20 mol of 50% methanol/toluene and balloon hydrogenated for 18 hrs in the presence of 0.4 gm of 50% by weight 10% Pd/C. The reaction mixture was filtered and evaporated to give the title product.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-05f188df39214e9698fe4f453bb0e209
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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