反应详情

To a mixture of methyl 2-(bromomethyl)acrylate (119 μl, 1 mmol) and K2CO3 (138 mg, 1 eq) in acetonitrile (2 ml) was added morpholine (96 μl, 1.1 mmols). The mixture was stirred overnight, filtered and concentrated. The residue was partitioned between ether and water, and organic layer was isolated, washed with brine and dried (MgSO4). Solvent was removed and residue was purified by column chromatography. Ethyl acetate eluted out the title compound as clear oil (110 mg, 59%).

1. filtrationfiltered
2. concentrationconcentrated
3. customThe residue was partitioned between ether and water
4. customorganic layer was isolated
5. washwashed with brine
6. dry with materialdried (MgSO4)
7. customSolvent was removed
8. customresidue was purified by column chromatography
9. washEthyl acetate eluted out the title compound as clear oil (110 mg, 59%)