HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-Dimethylaminomethyl-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Propenoic acid, 2-(bromomethyl)-, methyl ester | HCID 521093 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Dimethylaminomethyl-acrylic acid methyl ester | HCID 20669687 | — |
Reaction Steps
To a stirred solution of 2-bromomethyl-acrylic acid methyl ester (1 g, 5.59 mmol) in dry CH3CN (20 ml) was added 2M solution of dimethylamine in THF (3.07 ml, 6.14 mmol) followed by K2CO3 (0.93 g, 6.7 mmol). The reaction mixture was stirred overnight, filtered and washed with CH2Cl2. The filtrate was concentrated. The crude product was used in next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-1bb20791307e46b8a6e16c1945d357b2 |
| Source note | uspto-grants-2013_10 |