HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Benzyl-3-(1-hydroxy-ethyl)-pyrrolidine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 3-[1-(acetyloxy)ethyl]-1-(phenylmethyl)-3-pyrrolidinecarboxylate | HCID 57685792 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-3-(1-hydroxy-ethyl)-pyrrolidine-3-carboxylic acid methyl ester | HCID 57686370 | — |
Reaction Steps
2M HCl (25 ml) was added to a solution of 3-(1-Acetoxy-ethyl)-1-benzyl-pyrrolidine-3-carboxylic acid methyl ester (2N) (5 g, 16.39 mmol) in MeOH (50 ml) at room temperature, then refluxed for 2 hours. The solvent was evaporated yielding the product (4.39, 100%) ESMS (MH, 264).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-1182ddc97bed4e2b9be4b6cb55be8ced |
| Source note | uspto-grants-2013_10 |