Hydrochloric Acid → HCID 57685667, compound

Participants

Reaction Steps

4M HCl (2 ml) was added to a solution of 3-[3-(4-Fluoro-phenyl)-1Trityl-indazol-5-ylcarbamoyl]-3-formylamino-pyrrolidine-1-carboxylic acid tert-butyl ester (4P) 0.141 (mmol) in MeCl2 (2 ml) at room temperature, then stirred for 1 hour. The solvent was evaporated, hexanes added to residue and supernatant decanted. The residual solid was dried yielding 5P as a white solid (60 mg, 100%) LCMS (MH, 368.2) Retention time=1.91 minutes.

Provenance & Evidence