Hydrochloric Acid → HCID 57685667, compound

HRID 1038088Notes

Reaction equation

HRID 1038088 reaction equation
Cl.C(OC([N:9]1[CH2:13][CH2:12][C:11]([C:17](=[O:54])[NH:18][C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[N:24](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:23]=[C:22]3[C:47]2[CH:52]=[CH:51][C:50]([F:53])=[CH:49][CH:48]=2)([NH:14][CH:15]=[O:16])[CH2:10]1)=O)(C)(C)C>C(Cl)Cl>[F:53][C:50]1[CH:51]=[CH:52][C:47]([C:22]2[C:21]3[C:25](=[CH:26][CH:27]=[C:19]([NH:18][C:17]([C:11]4([NH:14][CH:15]=[O:16])[CH2:12][CH2:13][NH:9][CH2:10]4)=[O:54])[CH:20]=3)[NH:24][N:23]=2)=[CH:48][CH:49]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86614444HCID 86614444, compound

Product 1

HCID 57685667HCID 57685667, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4M HCl (2 ml) was added to a solution of 3-[3-(4-Fluoro-phenyl)-1Trityl-indazol-5-ylcarbamoyl]-3-formylamino-pyrrolidine-1-carboxylic acid tert-butyl ester (4P) 0.141 (mmol) in MeCl2 (2 ml) at room temperature, then stirred for 1 hour. The solvent was evaporated, hexanes added to residue and supernatant decanted. The residual solid was dried yielding 5P as a white solid (60 mg, 100%) LCMS (MH, 368.2) Retention time=1.91 minutes.

Workup

  1. customThe solvent was evaporated
  2. additionhexanes added to residue
  3. customsupernatant decanted
  4. customThe residual solid was dried

Sources & evidence

ORD record
ord-4e05f3cbc5a1453888dfd62ff852a1af
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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