Trifluoroacetic acid → HCID 57686277, compound

HRID 1038111Notes

Reaction equation

HRID 1038111 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:25]=[CH:24][C:23]([F:26])=[CH:22][N:21]=3)=[C:16]([F:27])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:26][C:23]1[CH:22]=[N:21][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)=[CH:15][C:16]=2[F:27])=[N:25][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58946487HCID 58946487, compound

Product 1

HCID 57686277HCID 57686277, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[3-Fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (21AB) (717 mg, 1.92 mmol, 1 equiv) was treated with 10% solution of trifluoroacetic acid in dichloromethane at room temperature overnight.

Sources & evidence

ORD record
ord-6eca9c2796d34656a8d2dbca88cc151e
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

Loading…