HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Nitro-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine → 2-(5-amino-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Nitro-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine | HCID 57686175 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(5-amino-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine | HCID 57685661 | 80% |
Reaction Steps
In a round-bottom flask equipped with a balloon, a mixture 2-(5-Nitro-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine (210 mg, 0.4 mmol) and 5% Pd on carbon (21 mg) in ethyl acetate and methanol (10 mL, 1:1) was hydrogenated overnight at room temperature to give 157 mg desired product (80% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-8aa526805e264a6888090ca3b7f0d6ec |
| Source note | uspto-grants-2013_10 |