HRID1038151

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=[N+]([O-])c1ccc2c(c1)c(-c1cc3cnccc3o1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID57686175

未命名化合物

PRODUCTS

生成物

结构：Nc1ccc2c(c1)c(-c1cc3cnccc3o1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID57685661

未命名化合物

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

In a round-bottom flask equipped with a balloon, a mixture 2-(5-Nitro-1-trityl-1H-indazol-3-yl)-furo[3,2-c]pyridine (210 mg, 0.4 mmol) and 5% Pd on carbon (21 mg) in ethyl acetate and methanol (10 mL, 1:1) was hydrogenated overnight at room temperature to give 157 mg desired product (80% yield).

WORKUP

后处理

customIn a round-bottom flask equipped with a balloon

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8aa526805e264a6888090ca3b7f0d6ec
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546404B2
来源说明: uspto-grants-2013_10

反应 SMILES

[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([C:13]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[N:8]=[C:7]2[C:32]1[O:40][C:39]2[CH:38]=[CH:37][N:36]=[CH:35][C:34]=2[CH:33]=1)([O-])=O>C(OCC)(=O)C.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([C:13]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[N:8]=[C:7]2[C:32]1[O:40][C:39]2[CH:38]=[CH:37][N:36]=[CH:35][C:34]=2[CH:33]=1