Methanesulfonic Acid → 2-Amino-5-[(methylsulfonyl)amino]benzenesulfonamide
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].NC1C=CC([N+]([O-])=O)=C[C:15]=1[S:23](N)(=[O:25])=[O:24].CS(O)(=O)=O.CS(Cl)(=O)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:23]([CH3:15])(=[O:25])=[O:24])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:10])=[O:11]Participants
Procedure
The 2-chloro-5-nitro-benzenesulfonamide intermediate (prepared as described in scheme 14) can be treated with a benzylic amine, such as benzylamine, to displace the chloro moiety. Hydrogenation under standard conditions in the presence of an acid (e.g., methanesulfonic acid) can be used to remove the benzylic group and to reduce the nitro group at the same time to afford the 2,5-diamino-benzenesulfonamide intermediate as a salt. Alternatively, the 2,5-diamino-benzenesulfonamide salt can be prepared by reduction of the 2-amino-5-nitro-benzenesulfonamide (prepared as described in schemes 14 and 15) under standard hydrogenation conditions in the presence of an acid (e.g., methanesulfonic acid). Subsequent reaction with methanesulfonyl chloride affords the desired 2-amino-5-methanesulfonylamino-benzenesulfonamide intermediate.
Sources & evidence
- ORD record
- ord-8861d4c4e6cd4916b95dac3226abd530
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08546602B2
Reaction notes
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