反应详情

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

1. additionis added
2. extractionthe resulting mixture is extracted with ethyl acetate
3. dry with materialThe organic phase is dried (sodium sulphate)
4. customthe solvent is removed
5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)