Hydrochloric Acid → HCID 68292626, compound

HRID 1038362Notes

Reaction equation

HRID 1038362 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](C)([C:14](O)=O)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.[ClH:18]>CO>[ClH:18].[CH3:1][O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 232828481-[(Tert-butoxy)carbonyl]-4-methylpiperidine-4-carboxylic acid

Product 1

HCID 68292626HCID 68292626, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 4-methyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.00 g, 4.10 mmol) in MeOH (2 mL) is added HCl (5 ml, 4 M in dioxane). After 18 h, the mixture is evaporated to dryness, the residue is dissolved in MeOH (3 mL), and the stirred solution is treated with Et2O (45 ml). The resulting solid is filtered and dried to give the title compound.

Workup

  1. customthe mixture is evaporated to dryness
  2. dissolutionthe residue is dissolved in MeOH (3 mL)
  3. additionthe stirred solution is treated with Et2O (45 ml)
  4. filtrationThe resulting solid is filtered
  5. customdried

Sources & evidence

ORD record
ord-b8228065813b4f079067e745b30fc58f
Source dataset
uspto-grants-2013_10
Patent number
US08551982B2

Reaction notes

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