(4-Chlorophenyl)methanesulfonyl chloride → HCID 67023880, compound

HRID 1038410Notes

Reaction equation

HRID 1038410 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]3[C:16]([C:17]#[N:18])=[C:15]([CH3:19])[NH:14][C:13]([CH3:20])=[C:12]3[C:21]#[N:22])[CH:9]=2)[N:4](C(OC(C)(C)C)=O)[N:3]=1.[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([CH2:37][S:38](Cl)(=[O:40])=[O:39])=[CH:33][CH:32]=1>>[C:17]([C:16]1[CH:11]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[NH:4][N:3]=[C:2]3[NH:1][S:38]([CH2:37][C:34]2[CH:35]=[CH:36][C:31]([Cl:30])=[CH:32][CH:33]=2)(=[O:39])=[O:40])[C:12]([C:21]#[N:22])=[C:13]([CH3:20])[NH:14][C:15]=1[CH3:19])#[N:18]

Participants

3

Reactant 2

HCID 227304(4-Chlorophenyl)methanesulfonyl chlorideHCID 24959832tert-Butyl 3-amino-5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazole-1-carboxylate

Product 1

HCID 67023880HCID 67023880, compound

Procedure

The title compound was prepared following the procedure described for Example 6 starting from 100 mg (0.256 mmol) tert-butyl 3-amino-5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazole-1-carboxylate (Example 3A) and 346 mg (1.54 mmol) (4-chlorophenyl)methane-sulfonyl chloride. Yield: 4 mg (3% of th.).

Sources & evidence

ORD record
ord-6bd97dedbd33414e9c00dbe1aa0b34fe
Source dataset
uspto-grants-2013_10
Patent number
US08551989B2

Reaction notes

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