HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038431Generated: October 26, 2026
3-Aminophenol → 3-((5-(4-(Trifluoromethyl)phenyl)oxazol-2-yl)amino)phenol
https://huagongshe.com/reaction/1038431
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 2-Chloro-5-(4-(trifluoromethyl)phenyl)oxazole | HCID 71060395 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-((5-(4-(Trifluoromethyl)phenyl)oxazol-2-yl)amino)phenol | HCID 71060269 | 40% |
Reaction Steps
A mixture of 2-chloro-5-(4-(trifluoromethyl)phenyl)oxazole 31 (0.511 g, 2.06 mmol) and commercially available 3-aminophenol 8 (0.225 g, 2.06 mmol) in 2-propanol (20 mL) was heated to 80° C. for 14 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide 3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenol 32 (0.26 g, 40% yield) as a solid. MS (ES) m/z 321 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08551992B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-0c8d8ff7258e4ff3b77863c207b73e0f |
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| Source note | uspto-grants-2013_10 |
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