反应详情

温度

80 °C

2-Hydroxy-5-nitro-nicotinic acid (2.7 mmol) in a mixture of N,N-dimethylformamide (2.7 mmol) and thionyl chloride (5 ml) was heated at 80° C. for 1 h. The mixture was allowed to cool and concentrated in vacuo. To the resulting residue was added ice-water (20 ml) and with vigorous stirring a precipitate formed. The precipitate was filtered off and dried in a vacuum oven to give a white solid (68%).

1. temperatureto cool
2. concentrationconcentrated in vacuo
3. additionTo the resulting residue was added ice-water (20 ml)
4. customformed
5. filtrationThe precipitate was filtered off
6. customdried in a vacuum oven