1-(2-Hydroxyethyl)piperazine → HCID 66598065, compound

HRID 1038510Notes

Reaction equation

HRID 1038510 reaction equation
Cl[C:2]1[CH:11]=[C:10]([CH2:12][CH2:13][CH3:14])[C:5]([C:6]([NH:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[N:15]1([CH2:21][CH2:22][OH:23])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>O1CCCC1>[OH:23][CH2:22][CH2:21][N:15]1[CH2:20][CH2:19][N:18]([C:2]2[CH:11]=[C:10]([CH2:12][CH2:13][CH3:14])[C:5]([C:6]([NH:8][CH3:9])=[O:7])=[CH:4][N:3]=2)[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 86647176HCID 86647176, compound

Product 1

HCID 66598065HCID 66598065, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
100 °C

Procedure

6-Chloro-N-methyl-4-propylnicotinamide (123 mg, 0.578 mol) was dissolved in tetrahydrofuran (2 mL), added 1-piperazineethanol (355 μL, 2.89 mol) at room temperature, and stirred at 100° C. for 18 hours. The reaction solution was purified by silica-gel column chromatography (chloroform/methanol). The title compound (177 mg (yield >99%)) was obtained as a yellow crystal.

Workup

  1. customThe reaction solution was purified by silica-gel column chromatography (chloroform/methanol)

Sources & evidence

ORD record
ord-4aa07126d17a48b585504acc903353f5
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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