反应详情

温度

70 °C

1-(4-Hydroxyphenyl)ethanone (15.0 g, 110 mmol) was dissolved in acetone (125 mL), added sequentially with potassium carbonate (30.4 g, 220 mmol) and 1-methylethyl iodide (16.5 mL, 165 mmol), and the mixture was stirred at 70° C. for 8 hours. The reaction solution was filtered, washed with acetone and concentrated in vacuo. The obtained residue was added water and ethyl acetate, extracted with ethyl acetate. The organic layer was washed with 1N aqueous solution of sodium hydroxide and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. 1-[4-(1-methylethoxy)phenyl]ethanone (18.2 g (yield 93%)) was obtained as a white crystal.

1. filtrationThe reaction solution was filtered
2. washwashed with acetone
3. concentrationconcentrated in vacuo
4. additionThe obtained residue was added water and ethyl acetate
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with 1N aqueous solution of sodium hydroxide and brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated in vacuo