tert-Butyl piperazine-1-carboxylate → 4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-nitrophenyl]piperazine-1-carboxylic acid tert-butyl ester

HRID 1038582Notes

Reaction equation

HRID 1038582 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([C:9]1[CH:14]=[CH:13][C:12](F)=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].[N:21]1([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[C:30]([O:29][C:27]([N:21]1[CH2:26][CH2:25][N:24]([C:12]2[CH:13]=[CH:14][C:9]([C:3]([OH:8])([C:2]([F:1])([F:19])[F:20])[C:4]([F:7])([F:5])[F:6])=[CH:10][C:11]=2[N+:16]([O-:18])=[O:17])[CH2:23][CH2:22]1)=[O:28])([CH3:33])([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 866472101,1,1,3,3,3-Hexafluoro-2-(4-fluoro-3-nitrophenyl)propan-2-ol

Product 1

HCID 866472094-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-nitrophenyl]piperazine-1-carboxylic acid tert-butyl ester

Procedure

1,1,1,3,3,3-Hexafluoro-2-(4-fluoro-3-nitrophenyl)propan-2-ol and tert-butyl piperazine-1-carboxylate were used for a similar reaction and treatment as Example 6-b), and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record
ord-699196e4b45b40c2936f6e0fd28d2127
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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