HCID 66597864, compound → 3-[2-((S)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-oxoethyl]-5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione

HRID 1038588Notes

Reaction equation

HRID 1038588 reaction equation
[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31]Br)[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1C2C=C(C3(C)NC(=O)NC3=O)C=CC=2CC1.[CH3:55][CH:56]([O:58][C:59]1[CH:60]=[CH:61][C:62]([C:65]2([CH3:72])[NH:69][C:68](=[O:70])[NH:67][C:66]2=[O:71])=[N:63][CH:64]=1)[CH3:57]>>[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31][N:67]3[C:66](=[O:71])[C:65]([C:62]4[CH:61]=[CH:60][C:59]([O:58][CH:56]([CH3:55])[CH3:57])=[CH:64][N:63]=4)([CH3:72])[NH:69][C:68]3=[O:70])[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 66597864HCID 66597864, compoundHCID 665980545-[5-(1-Methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dioneHCID 86647212HCID 86647212, compound

Product 1

HCID 866472143-[2-((S)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-oxoethyl]-5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione

Procedure

(S)-1-(4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-bromoethanone, 5-(2,3-dihydrobenzofuran-6-yl)-5-methylimidazolidine-2,4-dione and 5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Example 14-1, and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record
ord-39452a16b9a9471ebd0bac6e4c4601a7
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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