Ethyl Acetate → HCID 57710435, compound

HRID 1038672Notes

Reaction equation

HRID 1038672 reaction equation
[CH3:1][N:2]([CH3:17])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:15]=[C:14]([NH2:16])[N:13]=[CH:12][N:11]=2)[CH:6]=[CH:7][CH:8]=1.[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[N:26]=[C:27]=[O:28].C(OCC)(=O)C>O1CCOCC1>[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[NH:26][C:27]([NH:16][C:14]1[CH:15]=[C:10]([NH:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([N:2]([CH3:17])[CH3:1])[CH:4]=2)[N:11]=[CH:12][N:13]=1)=[O:28]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 5221622,6-Difluorophenyl isocyanateHCID 66669910HCID 66669910, compound

Product 1

HCID 57710435HCID 57710435, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of N-(3-dimethylamino-phenyl)-pyrimidine-4,6-diamine (458.6 mg, 2 mmol), 2,6-difluorophenyl isocyanate (341.2 mg, 2.2 mmol) in dry dioxane (5 mL) is shaken for 2.5 h at 80° C. After cooling down, the reaction mixture is treated with ethyl acetate. The precipitate is filtered off and dried in vacuo to afford the title compound.

Workup

  1. temperatureAfter cooling down
  2. filtrationThe precipitate is filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-910653c76a6243b19c8435d6cab930d0
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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