2,6-Difluorophenyl isocyanate → 1-(2,6-Difluoro-phenyl)-3-[6-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-urea

HRID 1038676Notes

Reaction equation

HRID 1038676 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[CH:19]=[C:18]([NH2:20])[N:17]=[CH:16][N:15]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=1[N:29]=[C:30]=[O:31]>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=1[NH:29][C:30]([NH:20][C:18]1[CH:19]=[C:14]([NH:13][C:10]2[CH:11]=[CH:12][C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[CH:8][CH:9]=2)[N:15]=[CH:16][N:17]=1)=[O:31]

Participants

3

Reactant 2

HCID 5221622,6-Difluorophenyl isocyanateHCID 66669896N-(4-Morpholin-4-yl-phenyl)-pyrimidine-4,6-diamine

Product 1

HCID 577104191-(2,6-Difluoro-phenyl)-3-[6-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-urea

Procedure

The title compound is prepared analogously as described in Example 105B from N-(4-morpholin-4-yl-phenyl)-pyrimidine-4,6-diamine and 2,6-difluorophenyl isocyanate. Slightly pink solid, HPLC: tR=3.53 min (purity: 100%, gradient F), ESI-MS: 427.4 [MH]+.

Sources & evidence

ORD record
ord-786e666673be406c88094b671abc17ab
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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