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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038676Generated: October 27, 2026

2,6-Difluorophenyl isocyanate → 1-(2,6-Difluoro-phenyl)-3-[6-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-urea

https://huagongshe.com/reaction/1038676

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Difluorophenyl isocyanateHCID 522162—
ReactantN-(4-Morpholin-4-yl-phenyl)-pyrimidine-4,6-diamineHCID 66669896—
Product1-(2,6-Difluoro-phenyl)-3-[6-(4-morpholin-4-yl-phenylamino)-pyrimidin-4-yl]-ureaHCID 57710419—

Reaction Steps

The title compound is prepared analogously as described in Example 105B from N-(4-morpholin-4-yl-phenyl)-pyrimidine-4,6-diamine and 2,6-difluorophenyl isocyanate. Slightly pink solid, HPLC: tR=3.53 min (purity: 100%, gradient F), ESI-MS: 427.4 [MH]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08552002B2
Source datasetuspto-grants-2013_10
ORD IDord-786e666673be406c88094b671abc17ab
Source noteuspto-grants-2013_10