Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| Reactant | 4-Amino-6-chloropyrimidine | HCID 238012 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66669976 | HCID 66669976 | — |
Reaction Steps
A mixture of 6-chloro-pyrimidin-4-ylamine (0.65 g, 5 mmol), 5-amino-2-methoxypyridine (0.62 g, 5 mmol) and 2-propanol (5 mL) is shaken for 36 h at 90° C. After cooling to room temperature, the reaction mixture is distributed between half-saturated Na2CO3-solution and ethyl acetate. The organic layer is dried over Na2SO4 and evaporated. The solid residue is washed consecutively with CH3OH, ethyl acetate and CH2Cl2 and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08552002B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-97421900b46645898253fef141036085 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
