Isopropanol → HCID 66669976, compound

HRID 1038681Notes

Reaction equation

HRID 1038681 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[N:14][CH:15]=1.CC(O)C.C([O-])([O-])=O.[Na+].[Na+]>C(OCC)(=O)C>[CH3:17][O:16][C:13]1[N:14]=[CH:15][C:10]([NH:9][C:2]2[CH:3]=[C:4]([NH2:8])[N:5]=[CH:6][N:7]=2)=[CH:11][CH:12]=1

Participants

6

Reactant 4

HCID 3776IsopropanolHCID 10340Sodium CarbonateHCID 811216-Methoxy-3-pyridinylamineHCID 2380124-Amino-6-chloropyrimidine

Product 1

HCID 66669976HCID 66669976, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 6-chloro-pyrimidin-4-ylamine (0.65 g, 5 mmol), 5-amino-2-methoxypyridine (0.62 g, 5 mmol) and 2-propanol (5 mL) is shaken for 36 h at 90° C. After cooling to room temperature, the reaction mixture is distributed between half-saturated Na2CO3-solution and ethyl acetate. The organic layer is dried over Na2SO4 and evaporated. The solid residue is washed consecutively with CH3OH, ethyl acetate and CH2Cl2 and dried in vacuo.

Workup

  1. temperatureAfter cooling to room temperature
  2. dry with materialThe organic layer is dried over Na2SO4
  3. customevaporated
  4. washThe solid residue is washed consecutively with CH3OH, ethyl acetate and CH2Cl2
  5. customdried in vacuo

Sources & evidence

ORD record
ord-97421900b46645898253fef141036085
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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