HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 66669942, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Aminobenzonitrile | HCID 16702 | — |
| Reactant | 6-chloro-N-methylpyrimidin-4-amine | HCID 309479 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 66669942 | HCID 66669942 | — |
Reaction Steps
A mixture of (6-chloro-pyrimidin-4-yl)-methylamine (1.44 g, 10 mmol), 3-amino-benzonitrile. (1.18 g, 10 mmol), 2-propanol (10 mL) and conc. HCl (0.45 mL, ˜5 mmol) is stirred for 36 h at 90° C. After cooling to room temperature, CH3OH is added and the reaction mixture is basified with conc. aqueous ammonia solution. The precipitate which forms upon addition of H2O is filtered off, washed with H2O and dried in vacuo to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552002B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-5c42ade4f2414fa59f3b3f0be07ce2be |
| Source note | uspto-grants-2013_10 |